CEO SUMMARY: Since 2014, a toxicology lab at the University of Colorado has used mass spectrometry to offer low-cost, accurate multi-analyte test panels that can detect hundreds of therapeutic drugs and drugs of abuse. However, CU Toxicology’s chief medical officer says health insurers are slow to accept this diagnostic technology, despite its demonstrated clinical benefit
Tag: tandem mass spectrometry
CEO Summary: Editor-In-Chief Robert L. Michel gave blood for the cause and it’s another laboratory industry first! To understand what doctors and patients see as national labs use different methodologies and reference ranges to report Vitamin 25(OH) D results, his blood was tested 24 times by nine laboratories. The results were unveiled at the Executive
CEO SUMMARY: As it developed a home brew mass spec assay for Vitamin 25(OH) D to meet the request of some client physicians, the laboratory at the University of Massachusetts Medical Center quickly recognized several challenges. First, there were fundamental differences in the numbers generated on the same population by the internally-developed LC-MS assay compared
CEO SUMMARY: Need proof that the issues surrounding today’s Vitamin 25(OH) D are of keen interest to laboratory professionals? Not only did the EXECUTIVE WAR COLLEGE’S in depth sessions on Vitamin D draw a large audience and enthusiastic participation by attendees, but within weeks, two of the lab industry’s most-watched magazines published headline stories about
FOR THE SECOND TIME in recent years, Editor Robert L. Michel and THE DARK REPORT have won a national award for “Best Investigative Reporting.”
In Washington, DC, last month, at the Specialized Information Publishers Association (SIPA) annual conference, Editor Michel learned that judges had bestowed the First Place award for “Best Investigative Reporting” to THE DARK
CEO SUMMARY: National headlines about erroneous Vitamin D results are a reminder to the lab industry of the imprecision and risks associated with home brew testing. According to one laboratory expert, every laboratory-developed test (LDT) must meet two high standards. One, accuracy, reproducibility, and transferability of the test result number. Two, a reference range that
CEO SUMMARY: Most laboratory professionals don’t know it yet, but significant changes occurred to the entire lab industry last week. After Quest Diagnostics Incorporated acknowledged that it was retesting tens of thousands of patients because 7% of the Vitamin D results it reported during an 18-month period were inaccurate, a blitz of newspaper headlines and
CEO SUMMARY: Having made the decision to perform nearly all Vitamin 25(OH) D testing by liquid chromatography–tandem mass spectrometry (LC–MS/MS), Quest Diagnostics Incorporated found the transition to be challenging. That was particularly true as the volume of Vitamin D specimens tripled at the nation’s largest lab company during the period May 2006 to May 2008.
ONE ASPECT IN THE DEBATE about the integrity of Vitamin D tests produced by liquid chromatography–tandem mass spectrometry (LC 0150MS/MS) is the discussion about how this method can produce results that are significantly higher than those produced by immunoassay-based methods. Quest Diagnostics addressed this point directly.
In response to questions from THE DARK REPORT, Wael Antoine
CEO SUMMARY: Those labs performing Vitamin 25(OH) D testing by mass spectrometry face an interesting challenge. For more than two decades, physicians, patients, and a majority of credible clinical studies have accepted RIA and IA Vitamin 25(OH) D results as a familiar standard. That is why, to avoid confusing physicians, some labs using the mass